Schafer R, Reagan P D
J Neurobiol. 1981 Mar;12(2):155-66. doi: 10.1002/neu.480120205.
Colchicine and some other microtubule-active agents inhibit the electrical responses of cockroach tibial spine mechanoreceptors. Lumicolchicine, a colchicine analog which does not bind to microtubule protein, does not inhibit mechanoreceptive responses. Colchicine inhibition of peripheral mechanoreceptive responses is fully reversible and dose dependent, but colchicine has no effect on conduction in leg nerve axons. Colchicine inhibition is therefore an effect on the sensory dendrites or soma. The inhibition produced by colchicine could be produced by several effects. Colchicine may inhibit because it (1) disrupts the numerous intracellular microtubules which are a part of this sensory receptor's dendrite, (2) blocks axoplasmic transport of essential materials to the sensory dendrite, or (3) binds to tubulin or other proteins in the dendritic membrane.
秋水仙碱和其他一些对微管有作用的药剂会抑制蟑螂胫刺机械感受器的电反应。光秋水仙碱是一种秋水仙碱类似物，它不与微管蛋白结合，不会抑制机械感受反应。秋水仙碱对外周机械感受反应的抑制作用是完全可逆的且呈剂量依赖性，但秋水仙碱对腿部神经轴突的传导没有影响。因此，秋水仙碱的抑制作用是对感觉树突或胞体产生的影响。秋水仙碱产生的抑制作用可能由多种效应导致。秋水仙碱可能因其（1）破坏了作为该感觉感受器树突一部分的大量细胞内微管，（2）阻断了向感觉树突的必要物质的轴浆运输，或（3）与树突膜中的微管蛋白或其他蛋白质结合而产生抑制作用。
