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抗Ig治疗后对来自瘙痒病感染小鼠的脾淋巴细胞加帽现象的观察

Observation on the capping of spleen lymphocytes from scrapie infected mice after treatment with anti Ig.

作者信息

Vettermann W, Werner H J, Schmeisser S, Koch M A

出版信息

Med Microbiol Immunol. 1981;169(2):75-81. doi: 10.1007/BF02171774.

DOI:10.1007/BF02171774
PMID:6163956
Abstract

Staining of lymphocytes from scrapie-infected STU mice with FITC-labelled anti-mouse Ig revealed disturbances in the capping process when compared with lymphocytes from mock-infected animals. Quantitative evaluation indicates that 10-15% of cells from scrapie-infected animals show an altered capping behaviour. These phenomena are discussed with special reference to the role of the lymphoreticular system in early scrapie agent replication.

摘要

用异硫氰酸荧光素标记的抗小鼠免疫球蛋白对感染羊瘙痒病的STU小鼠的淋巴细胞进行染色,结果显示,与模拟感染动物的淋巴细胞相比,其帽化过程受到干扰。定量评估表明,感染羊瘙痒病动物的细胞中有10%-15%表现出帽化行为改变。结合淋巴网状系统在羊瘙痒病病原体早期复制中的作用,对这些现象进行了讨论。

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Med Microbiol Immunol. 1981;169(2):75-81. doi: 10.1007/BF02171774.
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引用本文的文献

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Infect Immun. 1982 Jul;37(1):195-9. doi: 10.1128/iai.37.1.195-199.1982.

本文引用的文献

1
Failure to demonstrate a humoral immune response to scrapie infection in mice.未能在小鼠中证明对羊瘙痒病感染产生体液免疫反应。
J Immunol. 1973 Nov;111(5):1407-10.
2
Immunoglobulin determinants on the surface of mouse lymphoid cells.小鼠淋巴细胞表面的免疫球蛋白决定簇。
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Immunological responsiveness of scrapie infected mice.羊瘙痒病感染小鼠的免疫反应性。
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Experimental scrapie in the mouse: a review of an important model disease.小鼠实验性瘙痒病:一种重要模型疾病的综述
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