Kovács G L, Bohus B, De Wied D
Neurosci Lett. 1981 Feb 23;22(1):79-82. doi: 10.1016/0304-3940(81)90289-5.
Neuropeptides related to beta-endorphin (beta-LPH61-91) profoundly affect avoidance behavior. That gamma- and alpha-endorphin (beta-LPH61-77 and beta-LPH61-76, respectively) influence memory processes, has been investigated on rats. Using a one-trial learning, step-through passive avoidance paradigm, it was found that gamma-endorphin attenuates later retention of passive avoidance behavior when administered immediately or 3 h after learning; alpha-endorphin facilitates this response when given immediately after learning. Neither gamma- nor alpha-endorphin influence retention when the treatment is postponed for 6 h after learning. These data are interpreted as suggesting an opposite effect of gamma- and alpha-endorphin on consolidation processes.
与β-内啡肽（β-LPH61-91）相关的神经肽对回避行为有深远影响。γ-内啡肽和α-内啡肽（分别为β-LPH61-77和β-LPH61-76）对记忆过程的影响已在大鼠身上进行了研究。采用单次试验学习、穿梭式被动回避范式，研究发现，γ-内啡肽在学习后立即给药或学习后3小时给药时，会减弱被动回避行为的后期记忆；α-内啡肽在学习后立即给药时则促进这种反应。当学习后6小时才进行治疗时，γ-内啡肽和α-内啡肽均不影响记忆。这些数据被解释为表明γ-内啡肽和α-内啡肽对巩固过程有相反的作用。
