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口服避孕药、心脏瓣膜病和肺栓塞期间血清β-血小板球蛋白水平的变化(作者译)

[Changes in serum beta-thromboglobulin levels during oral contraception, cardiac valve disease and pulmonary embolism (author's transl)].

作者信息

Conard J, Terrier E, Baillet M, Horellou M H, Jaulmes B, Samama M, Baillet J

出版信息

Nouv Presse Med. 1981 Apr 11;10(16):1327-9.

PMID:6164044
Abstract

beta-thromboglobulin (beta TG), a platelet-specific protein, was measured in the plasma of 53 healthy subjects (20 men and 33 women), 53 women using estrogen-progestogen contraceptives, 31 patients with cardiac valve disease (including 19 with prosthesis) and 71 patients about to undergo scintigraphy for suspected pulmonary embolism. Compared with levels in healthy subjects, beta TG levels were significantly increased in oral contraceptive users and in cardiac patients with or without prosthesis. High beta TG levels were also found in 20 out of 28 patients with pulmonary embolism confirmed by scintigraphy, but also in some of the .9 lung patients with chronic bronchopulmonary disease. Cardiac patients treated with heparin had higher beta TG levels than non heparin-treated patients, which raises queries about a possible influence of heparin on this particular blood protein.

摘要

β-血小板球蛋白(βTG)是一种血小板特异性蛋白,在53名健康受试者(20名男性和33名女性)、53名使用雌激素-孕激素避孕药的女性、31名心脏瓣膜病患者(包括19名有假体的患者)以及71名因疑似肺栓塞即将接受闪烁扫描的患者的血浆中进行了测量。与健康受试者的水平相比,口服避孕药使用者以及有或无假体的心脏病患者的βTG水平显著升高。在28名经闪烁扫描确诊为肺栓塞的患者中,有20名患者的βTG水平也较高,但在一些患有慢性支气管肺病的患者中也有发现。接受肝素治疗的心脏病患者的βTG水平高于未接受肝素治疗的患者,这引发了关于肝素对这种特定血液蛋白可能产生影响的质疑。

相似文献

1
[Changes in serum beta-thromboglobulin levels during oral contraception, cardiac valve disease and pulmonary embolism (author's transl)].口服避孕药、心脏瓣膜病和肺栓塞期间血清β-血小板球蛋白水平的变化(作者译)
Nouv Presse Med. 1981 Apr 11;10(16):1327-9.
2
In vivo platelet activation following myocardial infarction and acute coronary ischaemia.心肌梗死和急性冠状动脉缺血后的体内血小板活化。
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3
[Beta-thromboglobulin and platelet regeneration time in children with mitral valve prolapse].[二尖瓣脱垂患儿的β-血小板球蛋白与血小板再生时间]
G Ital Cardiol. 1983 Oct;13(10):215-8.
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[beta-Thromboglobulin in plasma in patients with heart-valve diseases and with prosthetic heart valves (author's transl)].心脏瓣膜疾病患者和人工心脏瓣膜患者血浆中的β-血小板球蛋白(作者译)
Z Kardiol. 1980 Dec;69(12):815-7.
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Minerva Cardioangiol. 1984 Jun;32(6):387-91.
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Thromb Haemost. 1994 Dec;72(6):926-30.
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引用本文的文献

1
A study of embolism in mitral valve disease and atrial fibrillation.二尖瓣疾病和心房颤动中栓塞的研究。
Br Heart J. 1983 Feb;49(2):133-40. doi: 10.1136/hrt.49.2.133.