Cudillo L, Laghi F, Landolfi R, Leone G, Astore S, Pelargonio S, Bizzi B
G Ital Cardiol. 1983 Oct;13(10):215-8.
We studied 12 children with echocardiographic evidence of mitral valve prolapse (MVP) in order to demonstrate platelet activation or consumption as risk for thromboembolism. Therefore, with a standard radioimmunoassay, we measured the plasma levels of Beta-thromboglobulin (BTG), a platelet-specific protein released during platelet release reaction. Platelet turn-over was evaluated by measuring the Platelet Regeneration Time (PRT) with a non-radioisotopic method. Blood samples for BTG assay were collected at rest and after exercise. BTG plasma levels obtained in children with MVP were significantly higher than in normal subjects (p less than 0.01), both at rest and after exercise. We found no difference in either group between BTG level at rest and after exercise. The TRP was within the normal range in all patients except 2, in whom TRP was slightly shorter. Increased BTG levels and normal TRP suggest that in our patients platelet activation, but not consumption, was increased. In children with MVP, periodic controls of platelet activation may be useful to detect an increased risk of thromboembolism.
我们研究了12例有二尖瓣脱垂（MVP）超声心动图证据的儿童，以证明血小板激活或消耗作为血栓栓塞风险。因此，我们采用标准放射免疫分析法，测量了β-血小板球蛋白（BTG）的血浆水平，BTG是血小板释放反应期间释放的一种血小板特异性蛋白。通过用非放射性同位素方法测量血小板再生时间（PRT）来评估血小板周转率。用于BTG检测的血样在静息时和运动后采集。MVP患儿静息时和运动后的BTG血浆水平均显著高于正常受试者（p<0.01）。我们发现两组在静息时和运动后的BTG水平均无差异。除2例PRT略短的患者外，所有患者的PRT均在正常范围内。BTG水平升高而PRT正常表明，在我们的患者中血小板激活增加，而非消耗增加。对于MVP患儿，定期监测血小板激活可能有助于发现血栓栓塞风险增加。
