Haaheim L R
Acta Pathol Microbiol Scand B. 1980 Dec;88(6):351-3. doi: 10.1111/j.1699-0463.1980.tb02656.x.
An antigenic mutant of the wild influenza strain A/Texas/1/77 (H3N2) was obtained in vitro by growing virus of the allantosis-on-shell system in the presence of a mouse monoclonal antibody preparation to the Texas haemagglutinin (HA) antigen. A total of 204 human sera, from a population of randomly collected sera during the fall of 1979, were examined by the haemagglutination-inhibition (HI) tests against the Texas wild strain and the antigenic mutant. It was shown that sera from young children (0-5 years) reacted poorly, or not at all, with this mutant strain, whereas sera from adults (15 years +) reacted equally well with both viruses. It can be assumed that the antigenic site recognised by this particular monoclonal antibody preparation (185/1) may be important for the human immune response to the HA antigen of A/Texas/1/77 virus.
通过在存在针对得克萨斯血凝素（HA）抗原的小鼠单克隆抗体制剂的情况下，在鸡胚尿囊膜系统中培养野生型甲型流感病毒株A/得克萨斯/1/77（H3N2），在体外获得了一种抗原突变体。通过血凝抑制（HI）试验，针对得克萨斯野生株和抗原突变体，检测了1979年秋季随机收集的204份人血清。结果表明，幼儿（0至5岁）的血清与该突变株反应较差或根本无反应，而成年人（15岁及以上）的血清对两种病毒的反应同样良好。可以推测，被这种特定单克隆抗体制剂（185/1）识别的抗原位点可能对人类针对A/得克萨斯/1/77病毒HA抗原的免疫反应很重要。
