变形链球菌抗原诱导的抗原特异性猴T细胞抑制因子的免疫化学特性

Immunochemical properties of antigen-specific monkey T-cell suppressor factor induced with a Streptococcus mutans antigen.

作者信息

Lamb J R, Zanders E D, Kontiainen S, Lehner T

出版信息

Infect Immun. 1980 Dec;30(3):766-72. doi: 10.1128/iai.30.3.766-772.1980.

DOI:10.1128/iai.30.3.766-772.1980

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551381/

Abstract

Antigen-specific suppressor factor could be released from monkey suppressor T cells induced in vitro with a protein antigen isolated from the carcinogenic bacterium Streptococcus mutans. The suppressor activity was due to the factor itself and not to carryover of free antigen. Characterization of the monkey factor revealed it to have a molecular weight of ca. 70,000, and to contain a constant region and determinants encoded by the major histocompatibility complex. The presence of immunoglobulin determinants could not be demonstrated. However, by virtue of its adsorption to specific antigen, an antigen-combining site was shown to be present. The possible regulatory role of streptococcal antigen-specific suppressor factor in protection against dental caries is discussed.

摘要

抗原特异性抑制因子可从用从致龋菌变形链球菌中分离出的蛋白质抗原在体外诱导产生的猴抑制性T细胞中释放出来。抑制活性归因于该因子本身，而非游离抗原的残留。对猴因子的特性分析表明，其分子量约为70,000，并且包含一个恒定区和由主要组织相容性复合体编码的决定簇。未证实存在免疫球蛋白决定簇。然而，由于其对特异性抗原的吸附作用，表明存在一个抗原结合位点。文中讨论了链球菌抗原特异性抑制因子在预防龋齿中的可能调节作用。

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本文引用的文献

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Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备

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Specificity of antibodies induced by Streptococcus mutans during immunization against dental caries.变形链球菌在龋齿免疫过程中诱导产生的抗体的特异性。

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Nature. 1974 Oct 18;251(5476):652-4. doi: 10.1038/251652a0.

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Properties of antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. I. In vivo activity and immunochemical characterization.小鼠抗体应答调节中抗原特异性抑制性T细胞因子的特性。I. 体内活性及免疫化学特性

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