Lamb J R, Zanders E D, Kontiainen S, Lehner T
Infect Immun. 1980 Dec;30(3):766-72. doi: 10.1128/iai.30.3.766-772.1980.
Antigen-specific suppressor factor could be released from monkey suppressor T cells induced in vitro with a protein antigen isolated from the carcinogenic bacterium Streptococcus mutans. The suppressor activity was due to the factor itself and not to carryover of free antigen. Characterization of the monkey factor revealed it to have a molecular weight of ca. 70,000, and to contain a constant region and determinants encoded by the major histocompatibility complex. The presence of immunoglobulin determinants could not be demonstrated. However, by virtue of its adsorption to specific antigen, an antigen-combining site was shown to be present. The possible regulatory role of streptococcal antigen-specific suppressor factor in protection against dental caries is discussed.
抗原特异性抑制因子可从用从致龋菌变形链球菌中分离出的蛋白质抗原在体外诱导产生的猴抑制性T细胞中释放出来。抑制活性归因于该因子本身，而非游离抗原的残留。对猴因子的特性分析表明，其分子量约为70,000，并且包含一个恒定区和由主要组织相容性复合体编码的决定簇。未证实存在免疫球蛋白决定簇。然而，由于其对特异性抗原的吸附作用，表明存在一个抗原结合位点。文中讨论了链球菌抗原特异性抑制因子在预防龋齿中的可能调节作用。
