变形链球菌在猴子和小鼠中诱导产生特异性T细胞抑制功能。
Generation of specfic T-cell suppressor function induced by Streptococcus mutans in monkeys and mice.
作者信息
Lamb J R, Kontiainen S, Lehner T
出版信息
Infect Immun. 1979 Dec;26(3):903-9. doi: 10.1128/iai.26.3.903-909.1979.
Abstract
Specific suppressor cells in mice and monkeys can be induced with high doses of Streptococcus mutans antigen. When these cells are further cultured with a low dose of S. mutans antigen in vitro, they secrete specific suppressor factors which decrease the cooperative responses to this antigen. In view of the sensitivity of these cells to anti-Thy 1 and complement, and as they are not retained on nylon-wool, these suppressor cells are T cells. The suppressor factor exerts its effect on T helper cells and not on B cells. Suppressor cells and factors may regulate antibody responses to S. mutans and might be of significance in determining the dose and frequency of immunization and the type of adjuvant to be used.
摘要
用高剂量变形链球菌抗原可诱导小鼠和猴子体内产生特异性抑制细胞。当这些细胞在体外与低剂量变形链球菌抗原进一步培养时，它们会分泌特异性抑制因子，这些因子会降低对该抗原的协同反应。鉴于这些细胞对抗 Thy1 和补体敏感，且不能被尼龙毛柱滞留，所以这些抑制细胞是 T 细胞。抑制因子对 T 辅助细胞起作用，而不是对 B 细胞起作用。抑制细胞和因子可能调节对变形链球菌的抗体反应，在确定免疫剂量、频率以及所用佐剂类型方面可能具有重要意义。
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