Kontiainen S, Todd I, Feldmann M
Immunology. 1982 Mar;45(3):459-65.
KLH-specific suppressor factors produced in vitro efficiently diminished primary and secondary responses to trinitrophenyl keyhole limpet haemocyanin (TNP-KLH) in vivo. Both IgM and IgG responses were approximately equally affected, These suppressor factors were not genetically restricted, as allogeneic suppressor factors worked as efficiently as syngeneic factors. Furthermore, xenogeneic human suppressor factors were effective in mice and suppressed the responses as efficiently as syngeneic factors. The kinetics of the response in suppressed and non-suppressed mice was the same, indicating that the magnitude of the response was affected and not merely its time course. Prior injection with suppressor factor did not cause suppression of response, while suppressor factor injected at the same time as or soon after the antigen did, suggesting that it might act at the effector stage. The mechanism of action of this unrestricted suppressor factor, and the use of mouse model for in vivo testing of human suppressor factors is discussed.
体外产生的针对钥孔戚血蓝蛋白（KLH）的抑制因子能有效降低体内对三硝基苯基钥孔戚血蓝蛋白（TNP-KLH）的初次和二次反应。IgM和IgG反应受到的影响大致相同。这些抑制因子不受基因限制，因为同种异体抑制因子与同基因因子的作用效果一样好。此外，异种来源的人抑制因子在小鼠体内也有效，并且与同基因因子一样有效地抑制反应。被抑制和未被抑制的小鼠的反应动力学相同，这表明反应的强度受到影响，而不仅仅是其时间进程。预先注射抑制因子不会导致反应受到抑制，而在抗原注射的同时或之后不久注射抑制因子则会导致抑制，这表明它可能在效应阶段起作用。本文讨论了这种无限制抑制因子的作用机制，以及利用小鼠模型对人抑制因子进行体内测试的情况。
