假设：精原细胞瘤何时并非精原细胞瘤？

Raghavan D, Heyderman E, Monaghan P, Gibbs J, Ruoslahti E, Peckham M J, Neville A M

J Clin Pathol. 1981 Feb;34(2):123-8. doi: 10.1136/jcp.34.2.123.

A xenograft line, HX 53, has been established in immune-suppressed mice from a specimen of a lymph node metastasis in a patient with a histological diagnosis of seminoma but with markedly raised circulating levels of alpha-fetoprotein. Histological, immunocytochemical, and ultrastructural studies of this xenograft line have suggested that a solid variant of yolk sac carcinoma may exist, which morphologically resembles seminoma, or that a continuum of differentiation exists between seminoma and yolk sac carcinoma.

一个异种移植系HX 53已在免疫抑制小鼠中从一名组织学诊断为精原细胞瘤但甲胎蛋白循环水平显著升高的患者的淋巴结转移标本中建立。对该异种移植系的组织学、免疫细胞化学和超微结构研究表明，可能存在卵黄囊癌的实体变体，其形态上类似于精原细胞瘤，或者在精原细胞瘤和卵黄囊癌之间存在连续的分化。