豚鼠实验性变应性脑脊髓炎易感性的遗传分析。
Genetic analysis of susceptibility to experimental allergic encephalomyelitis in guinea-pigs.
作者信息
Raskin N H, Arnon R
出版信息
J Immunogenet. 1981 Apr;8(2):107-12. doi: 10.1111/j.1744-313x.1981.tb00748.x.
Abstract
Genetic analysis of susceptibility to experimental allergic encephalomyelitis (EAE) was performed in guinea-pigs. The results indicate the existence of two Ir genes to EAE in susceptible strain 13 guinea-pigs. One gene is linked to the major histocompatibility complex (MHC) of this species, while the other one is located outside the MHC. The two genes segregate independently and both of them must be expressed to render the animal susceptible to EAE.
摘要
对豚鼠进行了实验性变应性脑脊髓炎（EAE）易感性的遗传分析。结果表明，在易感的13系豚鼠中存在两个与EAE相关的Ir基因。一个基因与该物种的主要组织相容性复合体（MHC）连锁，而另一个位于MHC之外。这两个基因独立分离，且必须同时表达才能使动物对EAE易感。
相似文献
1
Genetic analysis of susceptibility to experimental allergic encephalomyelitis in guinea-pigs.豚鼠实验性变应性脑脊髓炎易感性的遗传分析。
J Immunogenet. 1981 Apr;8(2):107-12. doi: 10.1111/j.1744-313x.1981.tb00748.x.
2
Differing degrees of susceptibility to experimental allergic encephalomyelitis among inbred strains of hamsters.仓鼠近交系对实验性变应性脑脊髓炎的易感性存在不同程度差异。
Clin Immunol Immunopathol. 1983 Mar;26(3):370-9. doi: 10.1016/0090-1229(83)90121-6.
3
4
Genetic control of susceptibility to experimental allergic encephalomyelitis in rats.大鼠实验性变应性脑脊髓炎易感性的遗传控制
Science. 1973 Aug 31;181(4102):872-3. doi: 10.1126/science.181.4102.872.
5
Linkage of severity of experimental allergic encephalomyelitis to the rat major histocompatibility locus.实验性变应性脑脊髓炎的严重程度与大鼠主要组织相容性位点的连锁关系。
J Immunol. 1980 Apr;124(4):1815-20.
6
7
Genetic control of experimental autoimmune encephalomyelitis at the level of cytotoxic lymphocytes in guinea pigs.豚鼠细胞毒性淋巴细胞水平上实验性自身免疫性脑脊髓炎的遗传控制
Eur J Immunol. 1982 Sep;12(9):709-13. doi: 10.1002/eji.1830120903.
8
Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat.大鼠实验性变应性脑脊髓炎易感性与主要组织相容性位点的连锁关系。
J Exp Med. 1973 Oct 1;138(4):775-83. doi: 10.1084/jem.138.4.775.
9
Disparate MHC class II haplotypes in myelin oligodendrocyte glycoprotein- and myelin basic protein-induced experimental autoimmune encephalomyelitis.在髓鞘少突胶质细胞糖蛋白和髓鞘碱性蛋白诱导的实验性自身免疫性脑脊髓炎中不同的MHC II类单倍型
J Neuroimmunol. 2005 Apr;161(1-2):155-61. doi: 10.1016/j.jneuroim.2005.01.002.
10
Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat.实验性变应性脑脊髓炎的易感性与抗性：与大鼠下丘脑-垂体-肾上腺皮质轴反应性的关系
Endocrinology. 1999 Nov;140(11):4932-8. doi: 10.1210/endo.140.11.7109.
Zotero 插件