实验性变应性脑脊髓炎的严重程度与大鼠主要组织相容性位点的连锁关系。
Linkage of severity of experimental allergic encephalomyelitis to the rat major histocompatibility locus.
作者信息
Moore M J, Singer D E, Williams R M
出版信息
J Immunol. 1980 Apr;124(4):1815-20.
PMID:6767774
Abstract
The incidence of EAE is determined by Ir-EAE, a gene linked to the rat MHC. EAE severity can be assessed by quantitative clinical and pathologic measures. Using these measures, one can say that disease severity in LBNF1 is approximately one-tenth that in Lewis. Analysis of LBNF2, LBC, BNBC, and parental Lewis strain reveals that severity is primarily a function of dose of Lewis MHC alleles. Non-MHC genes have a small but discernable effect.
摘要
实验性自身免疫性脑脊髓炎（EAE）的发病率由Ir-EAE决定，Ir-EAE是一种与大鼠主要组织相容性复合体（MHC）相关的基因。EAE的严重程度可通过定量临床和病理学方法进行评估。利用这些方法，可以说LBNF1中的疾病严重程度约为Lewis中的十分之一。对LBNF2、LBC、BNBC和亲本Lewis品系的分析表明，严重程度主要是Lewis MHC等位基因剂量的函数。非MHC基因有微小但可察觉的影响。
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