Morison W L, Parrish J A, Woehler M E, Krugler J I, Bloch K J
J Invest Dermatol. 1981 Jun;76(6):484-8. doi: 10.1111/1523-1747.ep12521182.
Exposure of guinea pigs to UVA (320--400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290--320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7 days prior to immunization and for the 7 days between immunization and challenge (total period of radiation: 14 days) produced inhibiton of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7 days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses.
豚鼠经口灌胃给予8-甲氧基补骨脂素（简称PUVA）后暴露于UVA（320 - 400nm）辐射下，或暴露于UVB（290 - 320nm）辐射下，会导致暴露部位及远处未暴露部位的皮肤迟发型超敏反应受到抑制。在这些实验中，动物通过在完全弗氏佐剂中注射二硝基苯基 - 牛γ球蛋白（DNP - BGG）进行免疫，通过在侧腹皮内注射DNP - BGG、DNP和BGG激发迟发型超敏反应。在免疫前7天以及免疫与激发之间的7天（辐射总时长：14天），暴露于致红斑剂量的PUVA或UVB辐射下，会抑制对每种测试物质的反应。此外，在免疫前7天或在用DNP - BGG进行免疫与激发的间隔期内，用致红斑剂量的PUVA进行处理，会抑制照射部位及未暴露部位的迟发型超敏反应。这些发现表明，体内暴露于非电离辐射会导致某些免疫反应的局部和全身改变。
