Kalimo K, Koulu L, Jansén C T
Arch Dermatol Res. 1983;275(6):374-8. doi: 10.1007/BF00417336.
A single UVB or PUVA exposure given 4 days prior to skin testing affected skin responses both to contact allergens and to histamine and the histamine liberator, compound 48/80. The delayed contact hypersensitivity reactions were attenuated by UVB in 75% and by PUVA in 79% of the tests. The immediate skin reactions to histamine and compound 48/80 were diminished by UVB in 81% and by PUVA in 46% of the cases. While the epidermal Langerhans cell (LC) density was distinctly affected by irradiation, the attenuation of skin hypersensitivity reactions seemed to be independent of the degree of LC depletion. A significant correlation was, however, found between the strength of the erythemal reaction induced by the irradiation and the attenuation of the skin hypersensitivity test reactions; this was true for both delayed and immediate skin reactions in the case of UVB and for immediate skin reactions in the case of PUVA. The mechanism behind the attenuating effect of UV radiation on skin hypersensitivity reactions remains unknown, but it probably does not result from a stabilization of the mast cell membrane, as histamine and compound 48/80 induced reactions were suppressed to a similar extent.
在皮肤试验前4天进行单次UVB或PUVA照射，会影响皮肤对接触性变应原、组胺及组胺释放剂（化合物48/80）的反应。在75%的试验中，UVB可减弱迟发性接触性超敏反应，在79%的试验中PUVA可减弱该反应。在81%的病例中，UVB可减弱皮肤对组胺和化合物48/80的即刻反应，在46%的病例中PUVA可减弱该反应。虽然表皮朗格汉斯细胞（LC）密度受照射的影响明显，但皮肤超敏反应的减弱似乎与LC耗竭程度无关。然而，在照射引起的红斑反应强度与皮肤超敏试验反应的减弱之间发现了显著相关性；对于UVB，这在迟发性和即刻皮肤反应中均成立，对于PUVA，这在即刻皮肤反应中成立。UV辐射对皮肤超敏反应的减弱作用背后的机制尚不清楚，但它可能不是由肥大细胞膜的稳定化导致的，因为组胺和化合物48/80诱导的反应受到了类似程度的抑制。
