放射性碘治疗后使用卡比马唑对甲状腺辐射剂量的影响。
The effect of carbimazole following radioiodine therapy on radiation dose to the thyroid.
作者信息
Gimlette T M, Kocak R, Herbert R G, Squire C R
出版信息
Nuklearmedizin. 1981 Apr;20(2):72-5.
Radioiodine in the thyroid gland after a therapy dose of 131I was measured serially in 7 patients without Carbimazole, and in 11 patients starting Carbimazole 60 mg daily fourteen days after the therapy dose. Effective half-life for radioiodine in the gland initially 5.53 plus or minus 1.08 days fell to 4.26 plus or minus 1.12 days (p less than 0.01) during Carbimazole, and returned to 5.83 plus or minus 1.21 days (NS) after stopping the drug. The radiation dose to the thyroid from a given therapy dose of 131I followed by Carbimazole was calculated to be 97% of that without Carbimazole when he drug was started after 14 days, and 90% and 75% when the drug was started after 7 days and 1 day respectively.
对7名未服用卡比马唑的患者以及11名在治疗剂量后第14天开始每日服用60毫克卡比马唑的患者，连续测量了治疗剂量的131I进入甲状腺后的情况。甲状腺中放射性碘的有效半衰期最初为5.53±1.08天，在服用卡比马唑期间降至4.26±1.12天（p＜0.01），停药后又恢复至5.83±1.21天（无显著性差异）。在给予131I治疗剂量后14天开始服用卡比马唑时，计算得出卡比马唑对甲状腺的辐射剂量为未服用卡比马唑时的97%；若在7天和1天后开始服药，则分别为90%和75%。
Zotero 插件