Ichikawa Y, Takaya M, Arimori S
Tokai J Exp Clin Med. 1980 Oct;5(4):367-74.
Circulating immune complexes (IC) in patients with Sjögren's syndrome (SjS) were examined using the 125I-Clq binding method. IC were detected in 52% of the patients, and the highest incidences (80%) of IC were observed in SjS patients with systemic lupus erythematosus (SLE). IC were also demonstrated even in 40% of SjS patients without definite associated diseases. Several systemic manifestations suggesting participation of IC and hypocomplementemia were recognized in these IC-positive patients at the time of assay for IC. The levels of IC were positively correlated with both the erythrocyte sedimentation rate (ESR) and serum gammaglobulin in SjS patients. The incidences of IC increased in patients with severe sialographical changes in their parotid glands. The roles of circulating IC in advancement of the disease as well as in the occurrence of systemic manifestations in this syndrome were proven by the present results.
采用¹²⁵I-Clq结合法检测干燥综合征（SjS）患者的循环免疫复合物（IC）。52%的患者检测到IC，在合并系统性红斑狼疮（SLE）的SjS患者中IC的发生率最高（80%）。即使在40%无明确相关疾病的SjS患者中也检测到了IC。在检测IC时，这些IC阳性患者出现了一些提示IC参与和补体血症的全身表现。SjS患者的IC水平与红细胞沉降率（ESR）和血清γ球蛋白均呈正相关。腮腺严重涎腺造影改变的患者IC发生率增加。本研究结果证实了循环IC在该综合征疾病进展以及全身表现发生中的作用。
