Rotzsch W, Martin H, Martin R, Hellthaler G, Richter V
Z Gesamte Inn Med. 1981 Mar;36(5):131-7.
The biological ageing comprises changes of of structure and function depending on time with the beginning of the autonomy of a living being up to death. On the one hand, the causes of this process are genetically fixed, on the other hand they depend on environmental factors and are not programmed. In the course of life the total genome and also the nucleic acid underlie influences, which must have consequences on the gene expression. In these cases the changed sensitivity of the genetic apparatus in comparison to hormones is impressionably changed. The decreased protein biosynthesis may be stimulated by increased amino acid concentrations and by SH-substances, Age-depending changes are also observed for enzymatically catalyzed reactions and in the regulation of chains of metabolism. At first the biologic ageing appears as a complex multiform process, which reaches the simplest integration level in the cellular metabolism.
生物衰老包括从生物自主诞生到死亡期间，随时间推移而发生的结构和功能变化。一方面，这一过程的原因由基因决定；另一方面，它们取决于环境因素，并非预先设定的。在生命过程中，整个基因组以及核酸都会受到影响，这必然会对基因表达产生影响。在这些情况下，遗传机制相对于激素的敏感性会发生显著变化。蛋白质生物合成的减少可能会受到氨基酸浓度增加和含硫物质的刺激。在酶催化反应和代谢链调节方面也观察到了与年龄相关的变化。起初，生物衰老表现为一个复杂多样的过程，在细胞代谢中达到最简单的整合水平。
