Akizawa T, Nishiyama H, Koshikawa S
Artif Organs. 1981 Feb;5(1):54-8.
Impaired platelet function is commonly recognized in uremia. It is partially improved by dialysis. However, in regular hemodialysis patients (RD), platelet function is not fully evaluated. This study investigated platelet activity in chronic renal failure (CRF) using beta-thromboglobulin (BTG) as a marker. BTG in RD were significantly higher than those in non-dialyzed CRF patients (P less than 0.05), and BTG in non-dialyzed CRF were higher than in normal controls (P less than 0.01). In non-dialyzed CRF, BTG were correlated to serum creatinine value (P less than 0.01). Arteriovenous fistula did not affect BTG. Hemodialysis and direct hemoperfusion with charcoal beads increased BTG but neither peritoneal dialysis nor hemofiltration altered BTG. RD treated over one year showed higher BTG than those treated for less than one year (P less than 0.01). In RD who showed elevated BTG, platelet aggregation and retention rates were depressed and bleeding times were prolonged. These results indicate that BTG can be used as the marker of impaired platelet function in CRF and of the blood compatibility of artificial kidneys.
血小板功能受损在尿毒症中普遍存在。透析可使其部分改善。然而，对于常规血液透析患者（RD），血小板功能并未得到充分评估。本研究以β-血小板球蛋白（BTG）为标志物，调查了慢性肾衰竭（CRF）患者的血小板活性。RD患者的BTG显著高于未透析的CRF患者（P<0.05），未透析的CRF患者的BTG高于正常对照组（P<0.01）。在未透析的CRF患者中，BTG与血清肌酐值相关（P<0.01）。动静脉内瘘不影响BTG。血液透析和用活性炭珠进行直接血液灌流可使BTG升高，但腹膜透析和血液滤过均未改变BTG。透析超过一年的RD患者的BTG高于透析不足一年的患者（P<0.01）。在BTG升高的RD患者中，血小板聚集率和潴留率降低，出血时间延长。这些结果表明，BTG可作为CRF患者血小板功能受损及人工肾血液相容性的标志物。
