Lindsay R M, Friesen M, Koens F, Linton A L, Oreopoulos D, de Veber G
Clin Nephrol. 1976 Aug;6(2):335-9.
Platelet function studies were performed on 18 patients with end stage chronic renal failure receiving treatment by long-term peritoneal dialysis. The results of these studies were compared with previously reported data on healthy volunteers, non-dialyzed patients with chronic renal failure and patients treated by hemodialysis. Platelet adhesiveness was impaired and, unlike the other patient groups, there was no relationship between adhesiveness and serum creatinine. Platelet aggregation to both ADP and adrenaline chloride was normal, whereas marked impairment was seen in non-dialyzed patients with severe chronic renal failure and patients receiving hemodialysis. The results suggest that different uremic retention products affect these different phases in the platelet adhesion-aggregation reaction and that the peritoneal membrane is more permeable to that dialyzable factor which inhibits aggregation than conventional hemodialysis membranes. The studies are of interest both in consideration of adequacy of dialysis and in studies into the nature of the platelet defect in uremia.
对18例接受长期腹膜透析治疗的终末期慢性肾衰竭患者进行了血小板功能研究。这些研究结果与先前报道的健康志愿者、未透析的慢性肾衰竭患者以及接受血液透析治疗的患者的数据进行了比较。血小板黏附功能受损，与其他患者组不同的是，黏附性与血清肌酐之间没有关系。血小板对二磷酸腺苷（ADP）和氯化肾上腺素的聚集反应正常，而在未透析的重度慢性肾衰竭患者和接受血液透析的患者中则出现明显受损。结果表明，不同的尿毒症潴留产物影响血小板黏附 - 聚集反应的不同阶段，并且腹膜对抑制聚集的可透析因子的通透性比传统血液透析膜更高。这些研究对于考虑透析充分性以及研究尿毒症中血小板缺陷的性质都具有重要意义。
