淋巴毒素：一种抗癌淋巴因子，通过抑制化学致癌物或紫外线诱导的叙利亚仓鼠细胞转化来测定。
Lymphotoxin: an anticarcinogenic lymphokine as measured by inhibition of chemical carcinogen or ultraviolet-irradiation-induced transformation of Syrian hamster cells.
作者信息
Evans C H, DiPaolo J A
出版信息
Int J Cancer. 1981 Jan 15;27(1):45-9. doi: 10.1002/ijc.2910270108.
Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinogen treatment varies directly with lymphotoxin concentration. The frequency of transformation does not change following re-feeding with lymphotoxin-free medium and incubation for 6 additional days. Furthermore, transformation by ultraviolet is prevented when cells are pulsed with lymphotoxin for as few as 6 hours after irradiation. Thus, lymphotoxin has the potential to irreversibly inhibit the first recognizable morphologic step of carcinogenesis.
叙利亚仓鼠源淋巴毒素可抑制苯并(a)芘和紫外线致癌物诱导的二倍体传代二代仓鼠胚胎细胞的体外形态转化。当在致癌物处理后4天内添加淋巴毒素时，致癌物处理6天后形态转化频率的降低与淋巴毒素浓度直接相关。在用不含淋巴毒素的培养基重新培养并再孵育6天后，转化频率没有变化。此外，在照射后仅用淋巴毒素脉冲处理细胞6小时，就能阻止紫外线诱导的转化。因此，淋巴毒素有可能不可逆地抑制致癌作用中第一个可识别的形态学步骤。
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