Fournier G A, Lutty G A, Watt S, Fenselau A, Patz A
Invest Ophthalmol Vis Sci. 1981 Aug;21(2):351-4.
A corneal micropocket assay for angiogenesis in the rat eye is described in detail. With our test system, a partially purified, low molecular-weight endothelial cell growth stimulatory factor isolated from the Walker 256 rat carcinosarcoma is demonstrated to have potent angiogenic activity in vivo. The advantages and applications of our rat corneal assay are discussed.
详细描述了一种用于大鼠眼部血管生成的角膜微囊试验。在我们的测试系统中,从Walker 256大鼠癌肉瘤中分离出的部分纯化的低分子量内皮细胞生长刺激因子在体内被证明具有强大的血管生成活性。讨论了我们的大鼠角膜试验的优点和应用。