Kirschbaum B
Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
Am J Med Sci. 1998 Dec;316(6):393-7. doi: 10.1097/00000441-199812000-00007.
Plasma proteins, especially albumin, account for much of the normal anion gap. The relationship between globulins and the anion gap has not received much attention except for reports of a narrowing of the gap associated with certain monoclonal immunoglobulin G gammopathies. The author presents a patient with polyclonal gammopathy, the magnitude of which correlated strongly and positively with the anion gap, along with data from 400 patients attending a renal hypertension clinic, which show a significant positive correlation between the anion gap and total globulins. These results indicate that both albumin and globulin concentrations should be taken into account when attempting to explain abnormalities or changes in the magnitude of the gap.
血浆蛋白，尤其是白蛋白，构成了大部分正常的阴离子间隙。除了有关某些单克隆免疫球蛋白G型丙种球蛋白病导致阴离子间隙缩小的报道外，球蛋白与阴离子间隙之间的关系并未受到太多关注。作者报告了一名患有多克隆丙种球蛋白病的患者，该病的严重程度与阴离子间隙呈强正相关，同时还给出了400名肾性高血压门诊患者的数据，这些数据显示阴离子间隙与总球蛋白之间存在显著正相关。这些结果表明，在试图解释阴离子间隙大小的异常或变化时，应同时考虑白蛋白和球蛋白的浓度。
