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[口服酒精后大鼠扣带回第V层锥体神经元顶端树突棘的定量研究]

[Quantitative study of the apical dendritic spines in the cingulate lamina-V-pyramid neurons of the rat following oral application of alcohol].

作者信息

Schulz E, Schönheit B

出版信息

Z Mikrosk Anat Forsch. 1977;91(3):453-9.

PMID:616681
Abstract

The question answered in this paper is whether the apical dendritic spines-values of lamina-V-pyramidal cells of the gyrus cinguli of the rat are changed as a result of the oral application of ethanol. Alcohol-application causes a statistically significant increase of apical spines, especially at the main dendrite when given during the early postnatal development phase, where the brain is still impressible. The results are discussed as compensatory achievement of the not degeneratively changed neurons, while other pyramids show signs of degeneration. The conclusions were compared with the results of Kunz et al. (1976), who investigated the ethanol-effects on hippocampal pyramids.

摘要

本文所回答的问题是,大鼠扣带回第V层锥体细胞的顶端树突棘值是否会因口服乙醇而发生变化。在出生后早期发育阶段给予乙醇时,尤其是在主要树突上,酒精应用会导致顶端棘突在统计学上显著增加,此时大脑仍具有可塑性。研究结果被讨论为未发生退行性变化的神经元的代偿性成就,而其他锥体则显示出退行性变的迹象。研究结论与Kunz等人(1976年)的结果进行了比较,他们研究了乙醇对海马锥体的影响。

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