Weyand C, Hämmerling G J, Goronzy J
Nature. 1981 Aug 13;292(5824):627-9. doi: 10.1038/292627a0.
The polymorphic major histocompatibility antigens (H-2) have a crucial role in the activation of antigen-specific T lymphocytes. Thus, H-2 antigens are not only recognized by allogenic lymphocytes leading to generation of cytotoxic T lymphocytes (CTLs), but it has also been demonstrated that in syngeneic systems most T cells are only able to recognize foreign antigens in conjunction with their own MHC (major histocompatibility complex) antigens. This phenomenon, termed H-2 restriction, may be the key to our understanding to the biological function of MHC antigens. It is not clear whether recognition by T cells of H-2 on a molecular level is confined to particular domains on the H-2 molecule, nor whether the same polymorphic H-2 sites, which are characterized by antibodies, are recognized by allogeneic as well as by H-2 restricted syngeneic CTLs. Previous findings indicate the existence of at least two major polymorphic domains on the H-2Kk molecule as defined by antibodies. Here we show the existence of CTLs with specifity for these polymorphic domains, and the preferential recognition of a particular domain by both alloreactive as well as H-2 restricted CTLs.
多态性主要组织相容性抗原（H-2）在抗原特异性T淋巴细胞的激活中起关键作用。因此，H-2抗原不仅能被同种异体淋巴细胞识别，从而导致细胞毒性T淋巴细胞（CTL）的产生，而且还已证明，在同基因系统中，大多数T细胞仅能识别与自身主要组织相容性复合体（MHC）抗原结合的外来抗原。这种现象被称为H-2限制，可能是我们理解MHC抗原生物学功能的关键。目前尚不清楚T细胞在分子水平上对H-2的识别是否局限于H-2分子上的特定结构域，也不清楚由抗体所界定的相同多态性H-2位点是否能被同种异体以及受H-2限制的同基因CTL识别。先前的研究结果表明，根据抗体定义，H-2Kk分子上至少存在两个主要的多态性结构域。在此我们展示了对这些多态性结构域具有特异性的CTL的存在，以及同种异体反应性CTL和受H-2限制的CTL对特定结构域的优先识别。
