Papachristodoulou D, Brandenburg D, Dron D I, Jones R H, Sönksen P H, Thomas J H
Acta Biol Med Ger. 1977;36(11-12):1705-12.
The catabolism of insulins modified at the A1, B1 or B29 positions or containing a synthetic crosslink between the A1 and B29 positions has been studied in vivo and in vitro. The metabolic clearance rates (MCR) of insulin, proinsulin and chemically modified insulins have been measured by a priming-dose constant infusion technique in greyhounds. Insulins modified at A1 and B29, particularly the crosslinked materials, had markedly lowered MCR's whilst B1 analogues did not differ from insulin. Proinsulin and the A1-B29 crosslinked materials showed a markedly lowered degradability by glutathione-insulin transhydrogenase.
已在体内和体外研究了在A1、B1或B29位修饰的胰岛素或在A1和B29位之间含有合成交联的胰岛素的分解代谢。通过在灵缇犬中采用首剂量持续输注技术测量了胰岛素、胰岛素原和化学修饰胰岛素的代谢清除率（MCR）。在A1和B29位修饰的胰岛素，尤其是交联物质，其MCR显著降低，而B1类似物与胰岛素无差异。胰岛素原和A1-B29交联物质经谷胱甘肽-胰岛素转氢酶作用后显示出明显降低的降解性。
