Hylden J L, Wilcox G L
Brain Res. 1981 Jul 27;217(1):212-5. doi: 10.1016/0006-8993(81)90203-1.
Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.
给小鼠鞘内注射P物质引发了剂量相关的咬和抓挠反应。全身注射硫酸吗啡而非鞘内注射可拮抗此反应。我们对这些观察结果的解读是,定义了一种对鞘内P物质的新型伤害性反应。