Yamashita U, Clement L T, Shevach E M
J Immunol. 1981 Sep;127(3):1228-31.
A goat antibody specific for an antigenic determinant shared between guinea pig antithrombin III (AT III) and thymocytes was shown to be mitogenic for lymph node T lymphocytes in the presence of macrophages. Although the antiserum was not mitogenic for purified populations of B lymphocytes, B lymphocytes were as efficient as T lymphocytes in absorbing the mitogenic activity of the serum. The shared antigenic determinant appeared to be carbohydrate in nature in that native and guanidine-treated AT III, but not periodate oxidized AT III, were capable of inhibiting the mitogenic activity of the serum when added continuously to the cultures. The possibility that the plasma protease inhibitor AT III or an antigenically related membrane protein are involved in the regulation of T cell activation is discussed.
一种针对豚鼠抗凝血酶III（AT III）和胸腺细胞之间共享的抗原决定簇的山羊抗体，在巨噬细胞存在的情况下，对淋巴结T淋巴细胞具有促有丝分裂作用。尽管抗血清对纯化的B淋巴细胞群体没有促有丝分裂作用，但B淋巴细胞在吸收血清的促有丝分裂活性方面与T淋巴细胞一样有效。共享的抗原决定簇似乎本质上是碳水化合物，因为天然的和经胍处理的AT III，而不是经高碘酸盐氧化的AT III，在连续添加到培养物中时能够抑制血清的促有丝分裂活性。本文讨论了血浆蛋白酶抑制剂AT III或抗原相关膜蛋白参与T细胞活化调节的可能性。
