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[人表皮肿瘤细胞中多层上皮和A组链球菌共有的交叉反应性抗原的检测]

[Detection of a cross-reacting antigen common to multilaminar epithelia and group A streptococcus in cells of human epidermal tumors].

作者信息

Beletskaia L V, Berenbeĭn B A, Silagadze D G, Kolesnikova V Iu, Ezhov N Ia

出版信息

Biull Eksp Biol Med. 1981 Jun;91(6):712-4.

PMID:6168316
Abstract

The tissue-specific antigen of basal cells of human squamous epithelium which cross-reacts with streptococcal group A antigen has been detected in the cytoplasm of cells of human basal cell and squamous cells carcinomas histogenetically related to the skin epithelium. The antigen has not been detected in cells of tumors of endodermal origin (gastric and intestinal adenocarcinomas). These findings together with previous reports on the existence of cross-reactivity in case of animal tumors of ectodermal genesis may form the basis for an additional method of differential diagnosis of human tumors arising from the ectoderm-derived epithelium.

摘要

在与皮肤上皮组织发生学相关的人基底细胞癌和鳞状细胞癌的细胞胞质中,已检测到与人鳞状上皮基底细胞的组织特异性抗原,该抗原与A组链球菌抗原有交叉反应。在内胚层来源的肿瘤细胞(胃和肠腺癌)中未检测到该抗原。这些发现与先前关于外胚层起源的动物肿瘤存在交叉反应性的报道一起,可能为鉴别诊断源自外胚层衍生上皮的人类肿瘤提供一种额外的方法。

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