浆液性卵巢肿瘤淀粉酶（SONA）：一种对浆液性卵巢肿瘤可能有用的标志物。

Serous ovarian neoplastic amylase (SONA): a potentially useful marker for serous ovarian tumors.

作者信息

Van Kley H, Cramer S, Bruns D E

出版信息

Cancer. 1981 Sep 15;48(6):1444-9. doi: 10.1002/1097-0142(19810915)48:6<1444::aid-cncr2820480628>3.0.co;2-e.

DOI:10.1002/1097-0142(19810915)48:6<1444::aid-cncr2820480628>3.0.co;2-e

Abstract

A series of cystic ovarian tumors was studied with regard to amylase activity in the cyst fluid. Large amounts of amylase activity were present only in those patients with endosalpingeal-type lining epithelium (serous ovarian neoplasms). The amylase activity from two such patients was further characterized using G75 Sephadex chromatography, DEAE Sephadex chromatography, agarose gel chromatography, isoelectric focusing, and heat inactivation studies. Serous ovarian neoplastic amylase (SONA) exhibited properties different from amylases of pancreatic and salivary gland origin. Serous ovarian neoplastic amylase (SONA) may be a pancreatic and salivary gland origin. Serous ovarian neoplastic amylase (SONA) may be a useful biochemical marker in diagnosing and managing patients with serous ovarian neoplasms.

摘要

对一系列囊性卵巢肿瘤的囊液淀粉酶活性进行了研究。仅在那些具有输卵管内膜型衬里上皮（浆液性卵巢肿瘤）的患者中发现大量淀粉酶活性。使用G75葡聚糖凝胶色谱法、DEAE葡聚糖凝胶色谱法、琼脂糖凝胶色谱法、等电聚焦和热失活研究对两名此类患者的淀粉酶活性进行了进一步表征。浆液性卵巢肿瘤淀粉酶（SONA）表现出与胰腺和唾液腺来源的淀粉酶不同的特性。浆液性卵巢肿瘤淀粉酶（SONA）可能起源于胰腺和唾液腺。浆液性卵巢肿瘤淀粉酶（SONA）可能是诊断和管理浆液性卵巢肿瘤患者的一种有用的生化标志物。