Lankisch P G, Creutzfeldt W
Digestion. 1981;22(2):61-5. doi: 10.1159/000198596.
The action of synthetic and natural secretin on the human exocrine pancreas was compared. The trial was an intrasubject crossover comparison with randomized allocation of compounds in 12 healthy male subjects. No significant difference between compounds was found in bicarbonate, amylase and trypsin secretion after bolus injection. However, synthetic secretin evoked a significantly greater volume and amount of bicarbonate after infusion than the natural compound whilst no difference resulted in the other variables. It is concluded that synthetic secretin is suitable for testing the function of the exocrine pancreas.
对合成促胰液素和天然促胰液素对人体外分泌胰腺的作用进行了比较。该试验是一项受试者自身交叉比较，对12名健康男性受试者进行化合物随机分配。推注给药后，两种化合物在碳酸氢盐、淀粉酶和胰蛋白酶分泌方面未发现显著差异。然而，输注后合成促胰液素引起的碳酸氢盐分泌量和量明显大于天然化合物，而其他变量没有差异。结论是合成促胰液素适用于检测外分泌胰腺的功能。
