Shaw H L
J R Coll Gen Pract. 1977 Dec;27(185):742-5.
In a small group of hypertensive patients studied at home, once daily early morning sotalol therapy effectively decreased lying, standing, and post-exercise blood pressure and pulse rate. A dose-response relationship was seen. Adverse effects were mild and transient. The once daily regimen is easy to administer and appears to give precision in blood pressure reduction. Providing there is no subsequent escape from control, once daily beta-blocking therapy should aid long-term hypertension treatment in general practice.
在一小群在家中接受研究的高血压患者中,每天清晨服用一次索他洛尔疗法可有效降低卧位、立位及运动后的血压和脉搏率。呈现出剂量反应关系。不良反应轻微且短暂。每日一次的给药方案易于实施,且似乎能精准降低血压。倘若后续血压不会失控,那么每日一次的β受体阻滞剂疗法在一般医疗实践中应有助于长期高血压治疗。