长期每日一次服用阿替洛尔对高血压患者动态血压的影响。

Effects of long-term, once-daily administration of atenolol on ambulatory blood pressure of hypertensive patients.

作者信息

Floras J S, Jones J V, Fox P, Hassan M O, Turner K L, Sleight P

出版信息

J Cardiovasc Pharmacol. 1981 Sep-Oct;3(5):958-64. doi: 10.1097/00005344-198109000-00005.

DOI:10.1097/00005344-198109000-00005

Abstract

We measured intraarterial, ambulatory blood pressure over a 24-h period in 12 subjects 24--63 years (mean 47.6) of age with newly diagnosed untreated hypertension. Measurements were performed both before and after 2--9 months of once-daily treatment with atenolol, a cardioselective beta-adrenoceptor antagonist. Significant reductions in arterial pressure (p less than 0.005) during treatment with atenolol (dose range 50--200 mg) were observed over the full 24-h period.

摘要

我们对12名年龄在24至63岁（平均47.6岁）新诊断出未经治疗的高血压患者进行了24小时的动脉内动态血压测量。在使用阿替洛尔（一种心脏选择性β肾上腺素能受体拮抗剂）进行每日一次治疗2至9个月之前和之后均进行了测量。在使用阿替洛尔治疗期间（剂量范围为50至200毫克），观察到在整个24小时期间动脉压显著降低（p小于0.005）。