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人胎儿脑中的髓鞘碱性蛋白和胶质纤维酸性蛋白

Myelin basic protein and glial fibrillary acidic protein in human fetal brain.

作者信息

Borit A, McIntosh G C

出版信息

Neuropathol Appl Neurobiol. 1981 Jul-Aug;7(4):279-87. doi: 10.1111/j.1365-2990.1981.tb00099.x.

DOI:10.1111/j.1365-2990.1981.tb00099.x
PMID:6168966
Abstract

We demonstrated myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in tissue sections of routinely-processes premature human brain employing the peroxidase-antiperoxidase (PAP( method. The MBP immunostain delineated oligodendroglia before the appearance of myelin sheaths. The GFAP immunostain indicated that in addition to the stellate astrocyte, bouquet-shaped glia and radial glia are astrocytic in nature. The bouquet-shaped glia may be the normal counterpart for the gemistocytic astrocyte. The glia limitans stained with GFAP beginning with our first specimen. Small numbers of ependymal cells also contained cytoplasmic GFAP.

摘要

我们采用过氧化物酶-抗过氧化物酶(PAP)法,在常规处理的早产人类脑组织切片中检测了髓鞘碱性蛋白(MBP)和胶质纤维酸性蛋白(GFAP)。MBP免疫染色在髓鞘形成之前就勾勒出了少突胶质细胞。GFAP免疫染色表明,除了星状星形胶质细胞外,花束状胶质细胞和放射状胶质细胞本质上也是星形胶质细胞。花束状胶质细胞可能是肥胖型星形胶质细胞的正常对应物。从我们的第一个标本开始,胶质界膜就被GFAP染色。少数室管膜细胞也含有细胞质GFAP。

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