Roessmann U, Velasco M E, Sindely S D, Gambetti P
Brain Res. 1980 Oct 27;200(1):13-21. doi: 10.1016/0006-8993(80)91090-2.
Human ependymal cells show positive immunostaining for glial fibrillary acidic protein (GFAP) at one stage of the fetal development. The reaction seems to coincide with maturation of the epithelial layer and development of cilia. Two types of reactive cells are present: epithelial and tanycytes. The GFAP-positive reaction in both these cells is transient, appearing at different times and with different patterns in the various regions of the ventricular system. In order to explain the presence of detectable GFAP in developing ependymal cells and its absence in mature cells, it is proposed that either the synthesis of detectable amounts of GFAP occurs only at a stage of ependymal cell maturation, or that the intermediate filaments assembled in developing ependymal cell are antigenically distinct form those of the mature cells. The present findings indicate that tanycytes are not an immature from of ependymal cells but that they develop parallel to the epithelial cells. The role of the tanycytes remains obscure, but it is suggested that they are not related to radial glia.
人类室管膜细胞在胎儿发育的一个阶段对胶质纤维酸性蛋白（GFAP）呈阳性免疫染色。这种反应似乎与上皮层的成熟和纤毛的发育同时发生。存在两种反应性细胞：上皮细胞和伸展细胞。这两种细胞中的GFAP阳性反应都是短暂的，在脑室系统的不同区域出现的时间和模式不同。为了解释在发育中的室管膜细胞中可检测到GFAP的存在以及在成熟细胞中其不存在的情况，有人提出，要么仅在室管膜细胞成熟阶段才会合成可检测量的GFAP，要么发育中的室管膜细胞中组装的中间丝在抗原性上与成熟细胞的不同。目前的研究结果表明，伸展细胞不是室管膜细胞的未成熟形式，而是与上皮细胞平行发育。伸展细胞的作用仍然不清楚，但有人认为它们与放射状胶质细胞无关。
