Kerr I M, Wreschner D H, Silverman R H, Cayley P J, Knight M
Adv Cyclic Nucleotide Res. 1981;14:469-78.
With respect to interferon action in general: multisite models and analogies with hormone action are in vogue. More particularly, concerning the 2-5A system, the structure of 2-5A has been confirmed. We know that in the cell-free system and intact cell it is unstable and in the absence of a regenerating system transiently activates a nuclease. This nuclease shows some specificity; preferentially cleaving RNA on the 3'-side of UN doublets (UA and UU are preferred). When introduced into the intact cell 2-5A can inhibit protein and DNA synthesis and virus growth. In addition, both 2-5A and core occur naturally in amounts sufficient for them to play a part in the antiviral and antigrowth activities of interferon. Finally, it is possible that the 2-5A system may have a significance beyond its role in interferon action in the control of cell growth or development.
多部位模型以及与激素作用的类比很流行。更具体地说，关于2-5A系统，2-5A的结构已得到证实。我们知道，在无细胞系统和完整细胞中它是不稳定的，并且在没有再生系统的情况下会短暂激活一种核酸酶。这种核酸酶表现出一定的特异性；优先在UN双峰（UA和UU优先）的3'侧切割RNA。当引入完整细胞时，2-5A可抑制蛋白质和DNA合成以及病毒生长。此外，2-5A和核心物质天然存在的量足以使其在干扰素的抗病毒和抗生长活性中发挥作用。最后，2-5A系统在控制细胞生长或发育中可能具有超出其在干扰素作用中的意义。
