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DNA序列分析的计算机支持

Computer support of DNA sequence analysis.

作者信息

Osterburg G, Sommer R

出版信息

Comput Programs Biomed. 1981 Mar-Jun;13(1-2):101-9. doi: 10.1016/0010-468x(81)90088-x.

Abstract

The paper describes a package of APL-programs suited for the management and the analysis of DNA sequence data. Most of the application programs are related to experimental work in a DNA sequencing laboratory: Search for overlapping DNA fragments to construct complete DNA sequences; search for restriction sites; computing fragment patterns when cutting a DNA with restriction enzymes; plotting physical and genetic maps of a DNA; search for homologies as well as various counting procedures. More sophisticated programs are concerned with the prediction of RNA secondary structure and its graphical representation.

摘要

本文描述了一套适用于DNA序列数据管理和分析的APL程序包。大多数应用程序都与DNA测序实验室的实验工作相关:搜索重叠的DNA片段以构建完整的DNA序列;搜索限制酶切位点;计算用限制酶切割DNA时的片段模式;绘制DNA的物理图谱和遗传图谱;搜索同源性以及各种计数程序。更复杂的程序涉及RNA二级结构的预测及其图形表示。

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