Biber A, Englert D, Dommasch D, Hempel K
J Neurol. 1981;225(4):231-6. doi: 10.1007/BF00313295.
Cerebrospinal fluid (CSF) from 105 patients was analyzed by radioimmunoassay for the presence of material cross-reactive with peptide 89-169 of bovine myelin basic protein (BP). In a group of 72 multiple sclerosis patients, 52 showed higher BP content than the control group, i.e. more than 2 ng/ml CSF. Increased BP or BP fragments could be detected in CSF from almost all patients who recently (within 2 weeks) had had an acute episode, or after deterioration in the progressive form of the disease. Fifteen to 30 days after the onset of exacerbation or in a stable period, BP content decreases and in the slowly progressive form was in the range of the control group with one exception. BP content was also elevated in the CSF of patients with other neurological diseases. The presence of BP in the CSF from patients with isolated retrobulbar neuritis is of particular interest. Thus the presence of material cross-reactive with BP fragment 89-169 is not specific for multiple sclerosis, but is a useful parameter in diagnosis and evaluation of MS.
采用放射免疫分析法对105例患者的脑脊液（CSF）进行分析，以检测是否存在与牛髓鞘碱性蛋白（BP）89 - 169肽段发生交叉反应的物质。在72例多发性硬化症患者中，52例患者脑脊液中的BP含量高于对照组，即脑脊液中BP含量超过2 ng/ml。几乎所有近期（2周内）发生急性发作的患者，或疾病进展型病情恶化后的患者，其脑脊液中均可检测到BP含量升高或BP片段。病情加重后15至30天或病情稳定期，除1例例外，缓慢进展型患者的BP含量下降至对照组范围内。其他神经系统疾病患者的脑脊液中BP含量也升高。孤立性球后视神经炎患者脑脊液中存在BP尤其值得关注。因此，与BP片段89 - 169发生交叉反应的物质并非多发性硬化症所特有，但在多发性硬化症的诊断和评估中是一个有用的参数。
