Barna B P
Clin Lab Med. 1986 Mar;6(1):103-16. doi: 10.1016/S0272-2712(18)30828-X.
Multiple sclerosis (MS), a chronic disease with a relapsing and remitting course, is the most common neuroimmunologic condition in the United States. The hallmarks of the disease are focal demyelination and inflammation within the central nervous system (CNS). Because histopathologic changes can be identified only at autopsy, attention has been directed at formulating standardized clinical and laboratory procedures to aid in MS diagnosis. Currently, there are no MS-specific clinical or laboratory tests, but detection of abnormality in cerebrospinal fluid (CSF) IgG is important in supporting clinical evidence of disease. A number of other immunologic abnormalities have been recognized in MS, including the presence of T- and B-lymphocytes within the CNS and alterations in circulating suppressor T-lymphocytes. These findings have been interpreted as indicating disturbed immunoregulation associated with a chronic autoimmune response within the CNS. Evidence implicates viral infection in the pathogenesis of MS but the cause of the disease remains unknown.
多发性硬化症（MS）是一种具有复发-缓解病程的慢性疾病，是美国最常见的神经免疫性疾病。该疾病的特征是中枢神经系统（CNS）内的局灶性脱髓鞘和炎症。由于组织病理学变化只能在尸检时识别，因此人们一直致力于制定标准化的临床和实验室程序以辅助MS诊断。目前，尚无针对MS的特异性临床或实验室检查，但脑脊液（CSF）IgG异常的检测对于支持疾病的临床证据很重要。在MS中还发现了许多其他免疫异常，包括中枢神经系统内T淋巴细胞和B淋巴细胞的存在以及循环抑制性T淋巴细胞的改变。这些发现被解释为表明与中枢神经系统内慢性自身免疫反应相关的免疫调节紊乱。有证据表明病毒感染与MS的发病机制有关，但该疾病的病因仍然未知。
