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[大鼠戈莫里阳性下丘脑-垂体神经分泌系统对单剂量促甲状腺素释放激素的反应]

[Reaction of the Gomori-positive hypothalamo-hypophyseal neurosecretory system of the rat to a single dose of thyroliberin].

作者信息

Krasnovskaia I A, Tavrovskaia T V

出版信息

Probl Endokrinol (Mosk). 1981 May-Jun;27(3):48-52.

PMID:6170057
Abstract

A decrease in the functional neurosecretory cell activity of the rat hypothalamic supraoptical and paraventricular nuclei was seen 30 minutes after a single intramuscular thyroliberin injection (8 micrograms). The size of the neurosecretory cell nucleoli significantly diminished in both centers, while a large amount of intranuclear nucleoli-like bodies appeared in the paraventricular nucleus. The neurosecretory substance content in the posterior hypophysis significantly decreased, indicating an active neurohormone excretion. A possibility of negative feedback between the body thyroliberin level and the state of the Gomori-positive hypothalamic neurosecretory centers is discussed.

摘要

单次肌肉注射甲状腺释放激素(8微克)30分钟后,可见大鼠下丘脑视上核和室旁核的功能性神经分泌细胞活性降低。两个核团中神经分泌细胞核仁的大小均显著减小,而室旁核中出现大量核内核仁样小体。垂体后叶中神经分泌物质的含量显著降低,表明神经激素的排泄活跃。本文讨论了机体甲状腺释放激素水平与Gomori阳性下丘脑神经分泌中心状态之间存在负反馈的可能性。

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