Krasnovskaia I A
Biull Eksp Biol Med. 1981 Jul;92(7):88-9.
It has been shown that excess intramuscular injection of exogenous thyrotropin releasing hormone in a dose of 8 micrograms leads to a lowering of functional activity of the supraoptic and suprachiasmatic centers. This lowering was manifested by the reduced nucleolar size of neurosecretory cells. Nucleolar segregation seen in paraventricular and ventromedial nuclei of the hypothalamus attested to a pronounced suppression of RNA synthesis. No morphological changes were found in the arcuate nucleus. The role of the hypothalamic centers in the regulation of thyrotropin releasing hormone level is discussed.
已经表明，以8微克的剂量过量肌内注射外源性促甲状腺激素释放激素会导致视上核和视交叉上核的功能活性降低。这种降低表现为神经分泌细胞核仁大小减小。下丘脑室旁核和腹内侧核中出现的核仁分离证明RNA合成受到明显抑制。在弓状核中未发现形态学变化。讨论了下丘脑各中心在促甲状腺激素释放激素水平调节中的作用。
