Kantak K M, Hegstrand L R, Eichelman B
Pharmacol Biochem Behav. 1981 Sep;15(3):343-50. doi: 10.1016/0091-3057(81)90260-4.
Using two procedures known to enhance shock-induced defensive fighting (SIF) and mouse-killing--septal lesions and 5,7-DHT lesions--we determined if a 5% tryptophan-loaded diet could reverse the lesion effects. The results indicated that SIF, but not mouse-killing, could be maintained at normal levels following dietary tryptophan loading in both septally lesioned and 5,7-DHT lesioned rats. This behavioral reversal was independent of pain sensitivity, feeding, drinking and body weight levels. Regional brain analysis of monoamines and metabolites indicated that the lesions produced substantial depletions in 5-HT and 5-HIAA with minimal reduction or no change in catecholamines. Dietary tryptophan loading elevated 5-HT and 5-HIAA in unlesioned animals and partially restored 5-HT and 5-HIAA levels in lesioned animals. These patterns of depletion and repletion were confined to the hippocampus following septal lesions and distributed throughout the brain following 5,7-DHT lesions. The results are discussed in terms of a possible hippocampal mediation of the dietary tryptophan reversal in shock-induced defensive fighting following lesioning.
我们运用两种已知可增强电击诱导的防御性攻击行为（SIF）和杀鼠行为的方法——损毁隔区以及损毁5,7-二羟色胺（5,7-DHT），来确定富含5%色氨酸的饮食是否能够逆转这些损毁的影响。结果表明，在隔区损毁和5,7-DHT损毁的大鼠中，饮食中加载色氨酸后，SIF行为可维持在正常水平，但杀鼠行为却不能。这种行为逆转与疼痛敏感性、进食、饮水及体重水平无关。对单胺类物质和代谢产物进行的脑区分析表明，这些损毁导致5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）大量耗竭，而儿茶酚胺类物质仅有少量减少或未发生变化。饮食中加载色氨酸使未损毁动物的5-HT和5-HIAA水平升高，并使损毁动物的5-HT和5-HIAA水平部分恢复。隔区损毁后，这种耗竭和补充模式局限于海马体，而5,7-DHT损毁后则分布于整个大脑。本文将根据在损毁后电击诱导的防御性攻击行为中，饮食色氨酸逆转可能存在的海马体介导作用来讨论这些结果。
