Johnson P J, Melia W M, Palmer M K, Portmann B, Williams R
Br J Cancer. 1981 Oct;44(4):502-5. doi: 10.1038/bjc.1981.218.
An analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum alpha-foetoprotein (AFP)) influenced survival. Although survival was significantly longer in younger patients (P less than 0.02) and in patients with normal serum AFP (P less than 0.01), multivariate analysis showed that significant variation in survival time is better explained by the single factor, the presence of cirrhosis, than by AFP level. This does not seem to apply for patients with this tumour in Africa and the Far East, and there may be a fundamental difference in the natural history of the tumour between high- and low-incidence areas.
对57例西欧肝细胞癌患者的生存时间进行了分析，以确定几个可能的因素（年龄、性别、肝硬化和血清甲胎蛋白（AFP）升高）中哪些因素会影响生存。尽管年轻患者（P<0.02）和血清AFP正常的患者（P<0.01）的生存时间明显更长，但多因素分析显示，生存时间的显著差异用单一因素即肝硬化的存在来解释，比用AFP水平来解释更好。这似乎不适用于非洲和远东地区患有这种肿瘤的患者，高发病率地区和低发病率地区的肿瘤自然史可能存在根本差异。
