Thomas W J, Kelleher J F, Duval-Arnould B
Cancer. 1981 Dec 1;48(11):2371-4. doi: 10.1002/1097-0142(19811201)48:11<2371::aid-cncr2820481106>3.0.co;2-#.
Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3 1/2 years after metastasis and 2 1/2 years after stopping therapy. The main toxic reactions encountered were associated with the use of cis-platinum, but these were manageable and resolved upon completion of therapy. Cis-VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis-VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.
两名患有转移性性腺外内胚窦瘤且VAC化疗失败的儿童接受了由顺铂、长春碱、盐酸阿霉素（阿霉素）和博来霉素组成的联合化疗（顺铂-VAB）。两名患者均出现完全缓解，其中一名儿童在转移后3.5年及停止治疗后2.5年仍无肿瘤。主要的毒副反应与顺铂的使用有关，但这些反应是可控的，治疗结束后得以缓解。顺铂-VAB似乎是治疗转移性内胚窦瘤的一种安全有效的方案。似乎有必要对顺铂-VAB在更大一组预后不良的内胚窦瘤儿童中的疗效进行研究。
