Vogelzang N J, Anderson R W, Kennedy B J
Chest. 1985 Jul;88(1):64-9. doi: 10.1378/chest.88.1.64.
Three patients with endodermal sinus tumor of the mediastinum and two with endodermal sinus tumor mixed with other histologies were treated with CEBA (cisplatin, etoposide, bleomycin, and doxorubicin [Adriamycin]) and by cytoreductive surgery. Three patients treated with CEBA followed by surgery achieved a complete remission and remain free of disease at 36+, 35+, and 28+ months, respectively, from diagnosis. Two patients were treated initially with vinblastine, bleomycin, cisplatin, and surgery, and neither achieved a complete remission. Both then received CEBA, and one achieved a complete remission (duration 47 + months). Bone marrow toxicity from CEBA was severe, abrupt, and cumulative. All patients experienced neutropenic fever, anemia, and thrombocytopenia requiring platelet transfusions. The CEBA followed by vigorous cytoreductive surgery is effective treatment for germ cell tumors of the medastinum containing endodermal sinus tumor elements.
3例纵隔内胚窦瘤患者及2例内胚窦瘤合并其他组织学类型的患者接受了CEBA方案（顺铂、依托泊苷、博来霉素和多柔比星[阿霉素]）治疗并接受了减瘤手术。3例接受CEBA方案治疗后再行手术的患者分别在诊断后36 +、35 +和28 +个月时实现完全缓解且无疾病复发。2例患者最初接受长春碱、博来霉素、顺铂治疗并接受手术，但均未实现完全缓解。随后二者均接受CEBA方案治疗，其中1例实现完全缓解（持续时间47 +个月）。CEBA方案导致的骨髓毒性严重、突发且具有累积性。所有患者均经历了中性粒细胞减少性发热、贫血和血小板减少，需要输注血小板。CEBA方案后行积极的减瘤手术是治疗含有内胚窦瘤成分的纵隔生殖细胞肿瘤的有效方法。
