Rusch V W, Logothetis C, Samuels M
Chest. 1984 Nov;86(5):745-7. doi: 10.1378/chest.86.5.745.
Primary endodermal sinus tumor (EST) of the mediastinum has been regarded as a rare and rapidly fatal germ cell neoplasm. We describe two cases of extensive EST treated with a new high-dose sequential combination chemotherapy regimen (CISCA-VB) followed by radical surgical excision. They are alive at 11 and 20 months, respectively, postoperatively. These cases stand in marked contrast to previously reported series. A new approach to the management of this tumor is proposed.
纵隔原发性内胚窦瘤（EST）一直被视为一种罕见且迅速致命的生殖细胞肿瘤。我们描述了两例广泛型EST患者，采用新的高剂量序贯联合化疗方案（CISCA-VB）治疗，随后进行根治性手术切除。术后他们分别存活了11个月和20个月。这些病例与先前报道的系列形成了鲜明对比。我们提出了一种治疗该肿瘤的新方法。
