Assem E S, Attallah N A
Clin Allergy. 1981 Jul;11(4):367-74. doi: 10.1111/j.1365-2222.1981.tb01607.x.
A study was made of the significantly increased amounts of histamine released by anti-IgE from the leucocytes of asthmatic and allergic patients, particularly in patients with a low level of serum IgE. By measuring cell-bound IgE and histamine release with anti-IgE, particularly after passive sensitization of human leucocytes, it was possible to show that serum IgE in some allergic patients differed from that in normal subjects in two respects. Firstly, it appeared to have a relatively high leucocyte binding affinity, though this could not be proved conclusively. Secondly, and more importantly, IgE of some patients could more readily mediate histamine release with anti-IgE, that is to say it had a greater efficacy. These properties should be differentiated from another feature of allergic individuals, that is the more ready releasability of histamine from the patients' own leucocytes.
一项研究针对哮喘和过敏患者白细胞中抗 IgE 释放的组胺量显著增加展开，特别是血清 IgE 水平较低的患者。通过用抗 IgE 测量细胞结合 IgE 和组胺释放，尤其是在人白细胞被动致敏后，可以表明某些过敏患者的血清 IgE 在两个方面与正常受试者不同。首先，它似乎具有相对较高的白细胞结合亲和力，尽管这一点无法最终证实。其次，更重要的是，一些患者的 IgE 能用抗 IgE 更轻易地介导组胺释放，也就是说它具有更高的效能。这些特性应与过敏个体的另一个特征区分开来，即患者自身白细胞中组胺更容易释放。
