Reznik G, Hamlin M H, Ward J M, Stinson S F
Prostate. 1981;2(3):261-8. doi: 10.1002/pros.2990020304.
The prostates of 1775 (614 control and 1161 experimental) 2-year-old F344 rats from 12 different carcinogen bioassays conducted by the Bioassay Program of the NCI and the NTP were evaluated histologically. The incidence of prostatic lesions including (atypical) hyperplastic foci, adenomas, and carcinomas was 6.8%. There was no difference in the type or incidence of the lesions between treated and untreated animals. Adenomas or carcinomas were found in 71 (4.0%) of the rats, primarily as incidental findings. The number of tumors and hyperplastic foci varied from laboratory to laboratory depending on the anatomical localization of the plane of the section. Most of the neoplasms were found in the ventrolateral lobes of the prostate (ventral prostate). When adequate sections were prepared of the ventral lobe, 10-20% of the prostates had these proliferative lesions. The lesions were usually small and originated in the epithelium of the alveoli and small ducts and were usually small and originated in the epithelium of the alveoli and small ducts and were not associated with the common inflammatory lesions of the rat prostate. Thin fibrous capsules were formed in a few of the larger tumors. Metastases were not observed but there was local invasion into alveoli, ducts and interstitial connective tissue. Evidence is presented that the atypical hyperplasias progress to adenoma and carcinoma. The F344 rat offers a potential model for the study of latent prostatic preneoplastic and neoplastic lesions.
对来自美国国立癌症研究所（NCI）和国家毒理学计划（NTP）生物测定项目所进行的12项不同致癌生物测定中的1775只（614只对照和1161只实验）2岁F344大鼠的前列腺进行了组织学评估。前列腺病变（包括（非典型）增生灶、腺瘤和癌）的发生率为6.8%。经处理和未处理动物之间的病变类型或发生率没有差异。在71只（4.0%）大鼠中发现了腺瘤或癌，主要是偶然发现。肿瘤和增生灶的数量因实验室而异，这取决于切片平面的解剖定位。大多数肿瘤位于前列腺的腹外侧叶（腹侧前列腺）。当对腹侧叶制备足够的切片时，10%-20%的前列腺有这些增殖性病变。这些病变通常较小，起源于肺泡和小导管的上皮，通常不伴有大鼠前列腺常见的炎性病变。少数较大的肿瘤形成了薄纤维包膜。未观察到转移，但有局部侵犯肺泡、导管和间质结缔组织的情况。有证据表明非典型增生会发展为腺瘤和癌。F344大鼠为研究潜在的前列腺癌前病变和肿瘤性病变提供了一个潜在模型。
