成年大鼠中枢神经系统损伤后轴突向周围神经系统“桥接”部位的延伸。

Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.

作者信息

David S, Aguayo A J

出版信息

Science. 1981 Nov 20;214(4523):931-3. doi: 10.1126/science.6171034.

Abstract

The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as "bridges" between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.

摘要

利用一种新的实验模型，对成年大鼠局灶性中枢神经系统损伤后轴突生长的起源、终止和长度进行了研究。当使用外周神经节段作为延髓和脊髓之间的“桥梁”时，来自这两个水平神经元的轴突生长了约30毫米。当中枢神经系统的胶质环境转变为外周神经系统的胶质环境时，这些中枢神经元的再生潜能似乎得以表达。