Kramer F R, Mills D R
Nucleic Acids Res. 1981 Oct 10;9(19):5109-24. doi: 10.1093/nar/9.19.5109.
We observed the secondary structures that formed in an RNA molecule during its synthesis. Some of the secondary structures seen in nascent chains were observed to form, then to dissociate in favor of an alternative structure, and then to reform, as chain growth continued. The results show that secondary structures in an RNA molecule are in a state of dynamic equilibrium, and that the extension of a sequence by chain growth, or the reduction of a sequence by processing, may result in significant changes in the secondary structures that are present.
我们观察了RNA分子在合成过程中形成的二级结构。新生链中出现的一些二级结构先是形成，然后解离形成另一种结构，随着链的继续生长又重新形成。结果表明，RNA分子中的二级结构处于动态平衡状态，通过链生长延长序列或通过加工缩短序列，可能会导致现有二级结构发生显著变化。
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