Holmstrup P, Dabelsteen E, Roed-Petersen B
Scand J Dent Res. 1981 Jun;89(3):275-82. doi: 10.1111/j.1600-0722.1981.tb01683.x.
Thirty-eight biopsies of homogeneous oral leukoplakias were transplanted to subcutaneous sites of nude mice and protected from overlying cutaneous tissue by Millipore filters. The transplants were recovered after 21 d with a rate of successful recovery of 66%. The histologic epithelial features of the transplants were compared with those of the original leukoplakias. None of the leukoplakias from patients without tobacco habits lost the preexisting keratinization, whereas all 10 transplants demonstrating loss of keratinization belonged to patients with tobacco habits. This difference in behavior of transplanted leukoplakias from patients with and from patients without tobacco habits was statistically significant (P = 0.028). The results of the experimental study support the concept of two different types of leukoplakia, one possessing irreversible changes in epithelial keratinization, the other showing reversibility.
38块均质口腔白斑活检组织被移植到裸鼠的皮下部位，并通过微孔滤膜与上方的皮肤组织隔开。21天后取出移植组织，成功取出率为66%。将移植组织的组织学上皮特征与原始白斑的特征进行比较。没有吸烟习惯患者的白斑均未失去原有的角化，而所有10块出现角化丧失的移植组织均来自有吸烟习惯的患者。有吸烟习惯和无吸烟习惯患者的移植白斑在行为上的这种差异具有统计学意义（P = 0.028）。实验研究结果支持两种不同类型白斑的概念，一种上皮角化存在不可逆变化，另一种表现为可逆性。
